Welcome to the Keller Lab
The long-term goal of my research program is to reduce aflatoxin and sterigmatocystin contamination of food and feed crops. Aflatoxin (AF) and sterigmatocystin (ST) are toxic and carcinogenic secondary metabolites produced by the same biochemical pathway in several Aspergillus spp.
My program focuses on identifying the molecular genetic processes controlling expression of ST/AF biosynthesis and host metabolites which effect fungal growth and ST/AF biosynthesis. Results from these areas of research are directed towards designing rational ST/AF control strategies and should contribute to control of other fungal pathogens.
The Keller laboratory is located in room 3465 of the Microbial Sciences Building (map). Contact us by phone at (608) 262-1958.
Recent Keller Lab Papers
Lim F, Hou Y, Chen Y, Oh J, Lee I, Bugni T, Keller N,
Genome-based cluster deletion reveals endocrocin biosynthetic pathway in Aspergillus fumigatus.. . 2012 4; :
Yin W, Amaike S, Wohlbach D, Gasch A, Chiang Y, Wang C, Bok J, Rohlfs M, Keller N,
An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR.. Mol. Microbiol.. 2012 02; 83(5): 1024-34
PMC3288630Sanchez J, Somoza A, Keller N, Wang C,
Advances in Aspergillus secondary metabolite research in the post-genomic era.. Nat Prod Rep. 2012 02; 29(3): 351-71
PMC3288630Scherm B, Orrù M, Balmas V, Spanu F, Azara E, Delogu G, Hammond T, Keller N, Migheli Q,
Altered trichothecene biosynthesis in TRI6-silenced transformants of Fusarium culmorum influences the severity of crown and foot rot on durum wheat seedlings.. Mol. Plant Pathol.. 2011 09; 12(8): 759-71
PMC3288630Yin W, Keller N,
Transcriptional regulatory elements in fungal secondary metabolism.. J. Microbiol.. 2011 06; 49(3): 329-39
PMC3288630
